Seqitope™
a fast and highly accurate method for epitope mapping antibodies
We have developed an innovative method for antibody epitope mapping that serves multiple purposes. Seqitope™ is superior to other approaches for epitope mapping, as it yields high-resolution results while also being high throughput. Seqitope™ accelerates and supports the development of antibody-based drugs that are revolutionizing the treatment of cancer and autoimmune diseases.
What is Seqitope™?
There is a growing demand for fast, high-resolution, low-cost epitope mapping methods to serve the rapidly growing antibody market. Seqitope™ is a high-resolution, high-throughput method for antibody epitope mapping based on massive parallel mutagenic scanning. Up to a hundred monoclonal antibody (mAb) candidates can be run in parallel, which can streamline the development of antibody-based drugs as well as significantly reduce the cost of epitope mapping.
Beyond its core applications, our approach holds the potential for additional commercial value in several areas. These include vaccine design, understanding virus neutralization mechanisms, predicting virus evolutionary trajectories, enhancing the molecular resolution in diagnosing autoimmune diseases, and assisting in the affinity maturation of mAbs.
Our method "ticks all the boxes":
Why is it important?
Lead candidate selection by uncovering mechanisms of action is critical, as only antibodies that bind to a specific epitope on a target may produce the desired effect or, conversely, exert a pathological influence. This level of specificity is especially vital in the field of diagnostics. Moreover, epitope mapping is indispensable when it comes to filing patent applications and making regulatory submissions. Understanding the exact epitope that an antibody targets can provide a unique, defendable intellectual property position and is often a regulatory requirement.
What is epitope mapping?
Epitope mapping is understanding exactly where and how an antibody binds its target. This information is crucial during drug development, patent applications and regulatory submissions.